ProgenaMatrix® Description

ProgenaMatrix is a novel, advanced wound care product constructed from human keratin and is the only human keratin matrix commercially available.

The all-natural, robust human keratin protein that constitutes this specialized biomaterial offers a completely unique solution to wound care clinicians. The human keratin technology in ProgenaMatrix is hydrated, non-cellular (not tissue-based),resistant to degradation, and supports the body’s own healing process. The bio-inspired design makes ProgenaMatrix the next generation of advanced wound therapy in the CMS skin substitute category.

• • The matrix is made from all-natural components
  • – No synthetic ingredients
• • ProgenaMatrix is NON-CELLULAR and NOT TISSUE-BASED
• • ProgenaMatrix is a monolithic biomaterial made of protein and water
• • Keratin is the predominant protein with several keratin subtypes
  • – Contains other non-keratin proteins also
• • It is packaged in a sterile moisture-proof, peel-open pouch containing water and propylene glycol.

The Science of Keratin

These studies have inspired ProgenaCare to seek applications of keratin as a wound dressing.

Studies have proven that keratin stimulates keratinocyte migration and collagen synthesis, which is important for wound bed re-epithelialization. Keratin stimulates keratinocytes in vitro to produce increased Type IV and VII collagens which are central to basement membrane reconstitution during the healing process.1

Benefits of ProgenaMatrix

• • The only Human Keratin Matrix
• • Easy storage at room temperature; no fridge or freezer requirements
• • Long shelf life: 2 years and 10 Months
• • No need to rinse in sterile water or saline
• • Compatible with secondary dressings
• • Does not resorb or degrade into the wound
• • Per the IFU, “UP” embossment denotes the side which should be facing away from the wound
• • As the matrix dehydrates, the matrix corners & edges are prone to curl in the “UP” direction
• • ProgenaMatrix also contains a grid embossment
  • ° These lines demarcate 2cm increments
  • ° The smallest square created by the grid embossment is approximately 2cm x 2cm
• • Kosher certified
• • No cultural or religious barriers, unlike porcine or human-tissue based products

ProgenaMatrix is indicated for dry and exuding partial and full-thickness wounds such as:

• • Venous stasis ulcers
• • Diabetic foot ulcers
• • Pressure ulcers
• • Partial-thickness burns
• • Surgical wounds
• • Donor sites and grafts

ProgenaMatrix Instructions For Use

Ordering Information

Phone: (877)PROGENA (776-4362)
Email: sales@progenacare.com

Reimbursement

Q4222, ProgenaMatrix, Human Keratin Matrix, per cm2*

ProgenaMatrix Patient Support Program
Please contact our ProgenaMatrix Patient Support Program for all reimbursement-related questions.

Email: Reimbursement@progenacare.com
Reimbursement Support Hours 8:30am – 5:00pm ET, Monday – Friday

¹Tang L, Sierra JO, Kelly R, Kirsner RS, Li J. Wool-derived keratin stimulates human keratinocyte migration and types IV and VII collagen expression. Experimental Dermatology, 2012, 21, 458-460